James Cook led Derrick Henry in 2025 carries, 309 to 307, and rushing yards, 1,621 to 1,595. Overall, James Cook led 6 of 7 measured categories.
Derrick Henry (Baltimore, 17 games) against James Cook (Buffalo, 17 games). Every number below is measured, not projected.
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| Metric | Derrick Henry | James Cook |
|---|---|---|
| Carries | 307 | 309 ✓ |
| Rushing yards | 1,595 | 1,621 ✓ |
| Rushing touchdowns | 16 ✓ | 12 |
| Targets | 21 | 40 ✓ |
| Receptions | 15 | 33 ✓ |
| Receiving yards | 150 | 291 ✓ |
| Fantasy points | 279.5 | 302.2 ✓ |
Categories won: Derrick Henry 1, James Cook 6.
A future interpretation layer may add situational context to these measured comparisons. Its public availability remains unverified.
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Open gamedai freeJames Cook led Derrick Henry in 2025 carries, 309 to 307, and rushing yards, 1,621 to 1,595. Overall, James Cook led 6 of 7 measured categories.
James Cook led on carries (309 to 307). James Cook led on rushing yards (1,621 to 1,595). Derrick Henry led on rushing touchdowns (16 to 12).
Every figure is 2025 regular-season data from nflverse, published under CC BY 4.0. Nothing on the free half of this page is projected or estimated, and nothing on it came from a paywalled source.
James Cook led Derrick Henry in 2025 carries, 309 to 307, and rushing yards, 1,621 to 1,595. Overall, James Cook led 6 of 7 measured categories. James Cook led on carries, 309 to 307. James Cook led on rushing yards, 1,621 to 1,595. Derrick Henry plays at IND in week 1, Sun, Sep 13, 1:00 PM EDT. James Cook plays at HOU in week 1, Sun, Sep 13, 1:00 PM EDT. gamedai does not publish a weekly opponent-adjusted projection, an expert grade, or a crowd pick, so nothing here grades either fixture. Weigh a different pairing with the free start/sit tool at gamedai.app/tools/start-sit.
You picked between two players. Now bring that decision into your season room.
Open gamedai freeData from nflverse (nflverse-data), licensed CC BY 4.0. 2025 regular season, snapshot taken September 5, 2026. Source: nflverse-data. Licence: CC BY 4.0. gamedai is an independent analytics platform and is not affiliated with the National Football League.